Relationship between Serum Leptin, Ghrelin and Dietary Macronutrients in Women with Polycystic Ovary Syndrome

نویسندگان

  • Abdolrasoul Safaeiyan Department of Statistics and Epidemiology, Faculty of Health, Tabriz University of Medical Sciences, Tabriz, Iran
  • Bahram Pourghassem Gargari Nutrition Research Center, Department of Biochemistry and Diet Therapy, Faculty of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran
  • Laya Farzadi Women’s Reproductive Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  • Sheyda Houjeghani Department of Obstetrics and Gynecology, Faculty of Medicine, Tabriz Azad University of Medical Sciences, Tabriz, Iran
  • Shiva Houjeghani Students’ Research Committee, Faculty of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran
چکیده مقاله:

Background Polycystic ovary syndrome (PCOS) is the most common endocrinopathy in women. It may involve an impairment in physiologic regulation of leptin and ghrelin. There is limited, controversial data on the relation of dietary components with leptin and ghrelin in PCOS, so the current study has been conducted to explore the effects of different macronutrients on serum levels of leptin and ghrelin in PCOS and healthy subjects. MaterialsAndMethods In this case-control study, we randomly choose 30 PCOS patients and 30 healthy age and body mass index (BMI) matched controls. Intake of macronutrients [protein, total fat, saturated, monounsaturated and polyunsaturated fatty acids (PUFA), carbohydrate, dietary fiber] and energy were assessed using 3-day, 24-hour food recall and food frequency questionnaires (FFQ). Fasting hormonal status was measured for each participant. Results PCOS women had higher levels of serum leptin, insulin, testosterone, and luteinizing hormone (LH), whereas sex hormone-binding globulin (SHBG) was lower compared to healthy women. There was no significant difference in mean ghrelin concentrations between the groups. Among PCOS women, independent of BMI and total energy intake, we observed an inverse association between leptin concentration and total dietary fat (β=-0.16, P

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منابع مشابه

Relationship between Serum Leptin, Ghrelin and Dietary Macronutrients in Women with Polycystic Ovary Syndrome

BACKGROUND Polycystic ovary syndrome (PCOS) is the most common endocrinopathy in women. It may involve an impairment in physiologic regulation of leptin and ghrelin. There is limited, controversial data on the relation of dietary components with leptin and ghrelin in PCOS, so the current study has been conducted to explore the effects of different macronutrients on serum levels of leptin and gh...

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relationship between serum leptin, ghrelin and dietary macronutrients in women with polycystic ovary syndrome

background: polycystic ovary syndrome (pcos) is the most common endocrinopathy in women. it may involve an impairment in physiologic regulation of leptin and ghrelin. there is limited, controversial data on the relation of dietary components with leptin and ghrelin in pcos, so the current study has been conducted to explore the effects of different macronutrients on serum levels of leptin and g...

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عنوان ژورنال

دوره 9  شماره 3

صفحات  313- 321

تاریخ انتشار 2015-10-01

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